| 08:30 - 09:15 |
Registration |
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| 09:15 - 09:30 |
Welcome and Housekeeping |
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| 09:30 - 10:30 |
Plenary Session |
| "Chronicity, virulence and the pir multigene family" |
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| Professor Jean Langhorne, Francis Crick Institute, London, UK |
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| Sponsored by the Georgina Sweet Laureate Fellowship |
| Chairs: Daniel Fernandez-Ruiz and Dean Goodman |
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| 10:30 - 11:00 |
Morning tea |
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| 11:00 - 12:30 |
Session 1: Immunology |
| Sponsored by the Biomedicine Discovery Institute, Monash University |
| Chairs: Lynette Beattie and James O'Connor |
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| T1 | B cell responses to Plasmodium CSP are helped by T cells specific to alternative parasite antigens |
| Hayley A. McNamara, John Curtin School of Medical Research, Australian National University |
| T2 | Behaviour of resident memory T cells in the liver after malaria infection |
| Lauren E. Holz, Peter Doherty Institute |
| T3 | The most effective functional responses against P. falciparum merozoite invasion ligands are mediated by IgG3 subclass antibodies |
| Vashti Irani, Burnet Institute |
| T4 | Opsonic phagocytosis of sporozoites is an important mechanism in immunity against Plasmodium falciparum infection |
| Gaoqian Feng, Burnet Institute, Melbourne |
| T5 | Antibody responses to Plasmodium vivax Duffy Binding Proteins is associated with Gerbich homozygote blood type and protection from clinical malaria |
| Wen-Qiang He, Walter and Eliza Hall Institute |
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| 12:30 - 13:00 |
Short talk session I |
| Sponsored by Bio21 Institute |
| Chairs: Madi Njie and Evelyn Chou |
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| ST1 | Genetic origins of P. falciparum parasites with hrp2 gene deletions in Peru and Eritrea |
| Qin Cheng, Australian Army Malaria Institute |
| ST2 | Nationwide genetic surveillance of Plasmodium vivax in Papua New Guinea reveals heterogeneous transmission dynamics and routes of migration amongst subdivided populations |
| Abebe A. Fola, Walter and Eliza Hall Institute |
| ST3 | Quantifying parasite clearance in malaria: Rapid clearance but not easily altered |
| David S. Khoury, Kirby Institute |
| ST4 | Identification and characterisation of novel exported proteins in Babesia bovis |
| William A. Poole, Monash University |
| ST5 | Immunity to Plasmodium falciparum erythrocyte membrane protein1 and severe malaria in PNG |
| Janavi Rambhatla, Peter Doherty Institute |
| ST6 | Targeting CK1 for secretion: Novel mechanisms of vesicular trafficking in Plasmodium falciparum infected red blood cells |
| Mitchell Batty, Monash University |
| ST7 | Hofbauer cells in malaria in pregnancy |
| Isobel Walker, Bunet Institute |
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13:00 - 14:00 |
Lunch & Poster Session I (odd numbers) |
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| 14:00 - 15:30 |
Session 2: Molecular and Cellular Parasitology |
| Sponsored by Biomed Central/Malaria Journal |
| Chairs: Paul Sanders and Emma McHugh |
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| T6 | Identification of gene regulatory elements in the malaria parasite Plasmodium falciparum |
| Jingyi Tang, The University of Melbourne |
| T7 | Promiscuous splicing and sex: alternative splicing is required for gametocyte differentiation in Plasmodium berghei |
| Lee M. Yeoh, The University of Melbourne |
| T8 | The mechanism of malaria parasite entry into reticulocytes |
| Kaiseal Sarson-Lawrence, Walter and Eliza Hall Institute |
| T9 | Delayed death in the malaria parasite: Prenylation dependant disruption of intracellular trafficking |
| Kit Kennedy, The University of Melbourne |
| T10 | Proteostasis in the mechanism of action of artemisinin |
| Jessica L. Bridgford, Bio21 Institute |
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| 15:30 - 16:00 |
Afternoon tea |
| Sponsored by Agilent |
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| 16:00 - 17:30 |
Session 3: Mathematical Modelling and New Tools |
| Chairs: Philippe Boeuf and Leanna Surao |
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| T11 | BioStructMap: A Python tool for integration of protein structure and sequence-based features |
| Andrew Guy, Burnet Institute |
| T12 | Development of a decision-tool to guide the optimisation of intravenous artesunate dosing regimens for severe malaria patients
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| Sophie Zaloumis, The University of Melbourne |
| T13 | A method for quantifying artemisinin-induced growth retardation in blood-stage Plasmodium falciparum infection |
| Pengxing Cao, The University of Melbourne |
| T14 | Infrared research and diagnosis of malaria: From lab to the field |
| David Perez-Guaita, Monash University |
| T15 | Super resolution: a closer look at remodelling in Plasmodium falciparum infected red blood cells |
| Oliver Looker, Bio21 Institute |
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| 18:00 |
Conference dinner at The Loft |
| Sponsored by the Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne |
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| 8:30 - 9:00 |
Career development workshop with Professor Jean Langhorne |
| Chair: Ghizal Siddiqui |
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| 09:00 - 10:30 |
Session 4: Host-Parasite Interactions and Transmission |
| Sponsored by the Australian Society for Parasitology |
| Chairs: Louise Randall and Coralie Boulet |
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| T16 | Host erythrocyte phospho-signalling during infection with Plasmodium falciparum |
| Jack Adderley, Monash University |
| T17 | Malaria parasites resistant to the macrolide antimalarial azithromycin are not transmissible through mosquitoes |
| Hayley D. Buchanan, The University of Melbourne |
| T18 | Human to mosquito transmission of P. falciparum and P. vivax during controlled human malaria infection |
| Katharine A. Collins, QIMR |
| T19 | Association of Endothelial Protein C Receptor gene (procr) polymorphism with severe malaria and Anti-PfEMP1 antibodies |
| Digjaya Utama, Walter and Eliza Hall Institute |
| T20 | Direct quantification of host removal in Plasmodium berghei infection and the effects of antimalarial drugs on removal of parasites |
| Rosemary Aogo, Kirby Institute |
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| 10:30 - 11:00 |
Morning tea |
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| 11:00 - 12:30 |
Session 5: Systems Biology and Metabolism |
| Sponsored by The Monash Institute of Pharmaceutical Sciences |
| Chairs: David Gillett and Anna Sexton |
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| T21 | A systems biology approach indicates novel triazine compounds may impact a nuclear mechanism |
| Katherine M. Ellis, Monash Institute of Pharmaceutical Sciences |
| T22 | Elucidating the metabolic proof-reading capacity of P. falciparum |
| Laure Dumont, University of Melbourne |
| T23 | Metabolomics helps to unravel the mode of action of novel anti-malarial compounds |
| Anubhav Srivastava, Monash Institute of Pharmaceutical Sciences |
| T24 | Integrative analysis of the micro-RNA and mRNA response to human malaria infection using systems immunology |
| Martha Cooper, James Cook University |
| T25 | Glucose and iron metabolism in monocytes exposed to malaria |
| Ricardo Ataide, Burnet Institute |
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| 12:30 - 13:00 |
Short talk session II |
| Sponsored by Bio21 Institute |
| Chairs: Vern Lee and Jasmin Akter |
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| ST8 | Investigating the efficacy of triple artemisinin-based combination therapies (TACTs) in treatment of Plasmodium falciparum malaria using a mathematical model |
| Saber Dini, The University of Melbourne |
| ST9 | Ozonide antimalarials disrupt haemoglobin catabolism in Plasmodium falciparum |
| Carlo Giannangelo, Monash Institute of Pharmaceutical Sciences |
| ST10 | PlasmoCavalier: Identifying causal variants in haplotypes under selection |
| Somya Mehra, Walter and Eliza Hall Institute |
| ST11 | Characterisation of bromodomain proteins in the malaria parasite Plasmodium falciparum |
| Hahn H. T. Nguyen, The University of Melbourne |
| ST12 | Mitochondrial energy metabolism in liver stage of Plasmodium berghei |
| Upeksha L. Rathnapala, The University of Melbourne |
| ST13 | Understanding artemisinin action in Plasmodium falciparum |
| Natalie Spillman, The University of Melbourne |
| ST14 | Single cell analysis of the affinity and fate of CSP-specific B cells |
| Henry J. Sutton, Australian National University |
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| 13:00 - 14:00 |
Lunch and Poster Session II (even numbers) |
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| 14:00 - 15:30 |
Session 6: Epidemiology |
| Chairs: Rhea Longley and Eliza Davidson |
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| T26 | Impact of improved malaria control on the epidemiology of malaria in young Papua New Guinean children |
| Maria Ome-Kaius, PNG Institute of Medical Research |
| T27 | Var code: a new molecular epidemiology tool for monitoring Plasmodium falciparum in a high transmission area of Ghana, West Africa |
| Shazia Ruybal-Pesantez, Bio21 Institute |
| T28 | Dynamics of polymorphism in the leading Plasmodium falciparum vaccine candidate Reticulocyte Binding Protein Homologue 5 (RH5) |
| Elijah M. Martin, Walter and Eliza Hall Institute |
| T29 | Defining antibody kinetics and longevity to 40 Plasmodium vivax antigens in individuals from western Thailand |
| Zoe Shih-Jung Liu, Walter and Eliza Hall Institute |
| T30 | Effect of malaria infection, malaria exposure and gravidity on the immune response of peripheral blood mononuclear cells (PBMCs) derived from pregnant women |
| Marzieh Jabbarzare, Peter Doherty Institute |
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| 15:30 - 16:00 |
Afternoon tea |
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| 16:00 - 17:30 |
Session 7: Antimalarial Drugs |
| Sponsored by Medicines for Malaria Venture |
| Chairs: Ben Dickerman and Emily Crisafulli |
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| T31 | Retargeting the antibiotic azithromycin as an antimalarial with dual-modality |
| Amy Burns, The University of Adelaide |
| T32 | Characterization and classification of the MMV Pathogen Box anti-plasmodial compound sub-set |
| Sandra Duffy, Griffith University |
| T33 | Target validation and identification of novel boronate inhibitors of P. falciparum proteasome |
| Stanley Xie, Bio21 Institute |
| T34 | Drug targets in the apicoplast of malaria parasites |
| Taher Uddin, The University of Melbourne |
| T35 | Characterisation of the parasitological activity and mechanism of resistance of the aminomethylphenol, jpc-3210 for malaria treatment and prevention |
| Marina Chavchich, Australian Army Malaria Institute |
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| 17:30 - 18:00 |
Awards Ceremony and Closing remarks |
